How’s your epigenetic clock ticking? If you’re not sure or haven’t heard of it, it’s the measurement and prediction of your biological age. For the first time, researchers believe they’ve found and tested a hormone combination that can turn its wheels back and increase HGH (Human Growth Hormone).  Yes, they’re attempting to reverse aging in the human body.  While more research needs to take place, this is an incredibly promising and interesting study, with a lot of potential in anti-aging medicine.

What’s more, many lifestyle factors contribute to changes in your epigenetic clock. Make sure yours is ticking correctly for your healthiest aging.

THE WHEELS AND GEARS OF YOUR EPIGENETIC CLOCK

What makes up your epigenetic clock?

Put simply, it’s an assessment or time prediction of your epigenome. Your epigenome is the compilation of chemical modifications your body makes to your DNA in your cells as you live.  In addition, your epigenetic clock can tell scientists more about your mortality risk, and the lifestyle factors contributing to your biological age. You may be accelerating it. You may be able to slow down. (1).

THE THYMUS GLAND’S AGE AND FUNCTION

While studying the epigenome, scientists have identified several key DNA sites in the body that best represent DNA-methyl tags and biological age. This current study centered around the thymus gland. The thymus gland is crucial for effective immune function. After white blood cells are produced in the bone marrow, they are sent to the thymus to mature and specialize. Unfortunately, the thymus begins to deteriorate after puberty and becomes clogged with fat as we age and Human Growth Hormone production (HGH) slows down or stops completely.

THE STUDY: REVERSE AGING IN THE THYMUS

In the scientific community, it’s been long known that Human Growth Hormone (HGH) stimulates regeneration in the thymus, in addition to Human Growth Hormone (HGH), the researchers used 2 anti-diabetes medications, dehydroepiandrosterone (DHEA) and metformin.  For one entire year, 9 healthy participants took a combination of Human Growth Hormone (HGH), dehydroepiandrosterone (DHEA), and metformin each day. Their biological age was assessed at the beginning, throughout the study, the end, and 6 months thereafter.

THE RESULTS: INCREASED GROWTH HORMONE, FOREVER YOUNG?

After completion of the year-long trial, the participants reduced their biological ages by 2.5 years. Their immune systems specifically showed signs of rejuvenation, or reverse aging. Maybe the most exciting point is that the rejuvenation of the thymus gained momentum towards the end of the study. The rate at the end of the study, from 9-12 months, was -6.5 years per year. What’s more, the effects persisted for 6 months after the discontinuation of the medications. This means that not only did normal aging of the thymus halt, but it actually reversed. (2).

LOOKING AHEAD AND TURNING BACK TIME

Most scientists are surprised. Based on previous studies, they thought intervention could likely stop aging at DNA-methyl sites, but not reverse it.

According to the researchers, this was the first report of an increase, based on an epigenetic age estimator, in predicted human lifespan by an accessible intervention (3).

Now, other researchers are testing the individual medications used alongside Human Growth Hormone (HGH), to see if they are contributing separately to anti-aging mechanisms. They are optimistic that rejuvenating the thymus could offer help to those with struggling immune systems, the elderly, those with illnesses that attack immune function, and more.

INCREASE HGH: NATURAL AGE-DEFYING LIFESTYLE HABITS

In addition to Human Growth Hormone (HGH) and medications, many lifestyle factors affect epigenome patterns.

  • Diet
  • Weight
  • Physical activity
  • Tobacco smoking
  • Alcohol consumption
  • Environmental pollutants
  • Psychological Stress
  • Working Night Shifts

This means there’s good news, bad news.

First, the bad: What you do matters for your aging and health, even at the cellular DNA level. Second, the good:  You can make a difference in your aging and health by choosing healthy lifestyle habits to increase HGH (Human Growth Hormone).

  • https://pubmed.ncbi.nlm.nih.gov/29337038/
  • https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028
  • https://www.nature.com/articles/d41586-019-02638-w